LABOTEST-BB LT00233142
3,3-Tetramethyleneglutarimide
CAS: 1075-89-4
Molecular Formula: C9H13NO2
LABOTEST-BB LT00233142 - Names and Identifiers
| Name | 3,3-Tetramethyleneglutarimide |
| Synonyms | AZA-8 LABOTEST-BB LT00233142 TETRAMETHYLENE GLUTARIMIDE 1,1-cyclopentanedlacetimide 1,1-cyclopentanediacetimide 3,3-Tetramethyleneglutarimide 3,3-TETRAMETHYLENEGLUTARIMIDE 8-Azaspiro[4.5]decane-7,9-dione 8-AZASPIRO[4,5]DECANE-7,9-DIONE 8-Azaspiro[4,5]decane-7,9-Dione BETA,BETA-TETRAMETHYLENEGLUTARIMIDE |
| CAS | 1075-89-4 |
| EINECS | 427-770-4 |
| InChI | InChI=1/C9H13NO2/c11-7-5-9(3-1-2-4-9)6-8(12)10-7/h1-6H2,(H,10,11,12) |
LABOTEST-BB LT00233142 - Physico-chemical Properties
| Molecular Formula | C9H13NO2 |
| Molar Mass | 167.21 |
| Density | 1.1222 (rough estimate) |
| Melting Point | 153-155 °C |
| Boling Point | 295.79°C (rough estimate) |
| Flash Point | 162.6°C |
| Vapor Presure | 4.31E-05mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| BRN | 383702 |
| pKa | 11.71±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4760 (estimate) |
| Physical and Chemical Properties |
|
LABOTEST-BB LT00233142 - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 28 - Very Toxic if swallowed |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1 / PGIII |
| HS Code | 29251995 |
| Hazard Class | 6.1 |
| Packing Group | III |
LABOTEST-BB LT00233142 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 3, 3-tetramethylene glutarimide is a commonly used intermediate in the preparation of certain drugs, at present, most of them are used for the preparation of anti Anxiety drug buspirone hydrochloride, and are the key intermediates for the preparation of this kind of drugs. |
| preparation | CN92108607.5 a new preparation method of 3, 3-tetramethylene glutarimide is reported: 1,1-cyclopentane diacetic acid and urea in the ratio of 1: 1.1-1: 1.6 (molar ratio), at 0.5-200 deg C stirring reaction for -2 hours, after the reaction, the crude 8-azaspiro [4,5] decane -7, 9-dione compound was obtained, and then recrystallized from 30-60% ethanol and activated carbon to obtain white crystal 3,3-tetramethylene glutarimide compound, yield 80.1-89.5%, melting point 154-156 °c. The urea used is a commercially available and inexpensive raw material, and there is no special requirement for the reaction equipment because no acetic anhydride is used. At the same time, the method of the present invention simplifies the reaction steps compared with the prior art, the invention has low cost of raw and auxiliary materials and simple equipment. The advantage of a short reaction time. Particularly suitable for industrial production. |
Last Update：2024-04-09 21:01:54
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View History
LABOTEST-BB LT00233142
3-TRITYLSULFANYL-PROPIONIC ACID
2-氯-5-(三氟甲基)吡啶-3-磺酰胺
4-乙基硝基苯
4,7-二氮杂螺[2.5]辛烷-4-甲酸叔丁酯
DIETHYL (3-(METHOXYCARBONYL)PHENYL)METHYLPHOSPHONATE
oxygen(-2) anion
METHYL BROMOACETATE SOLUTION 100UG/ML IN T-BUTYLMETHYL ETHER 5X1ML
5-氟-2-甲基-3-硝基苯甲酸甲酯 2-甲基-3-硝基-5-氟苯甲酸甲酯
LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-GLY-ALA-PRO-LEU-ALA-PRO-ARG-ASP-ALA-GLY SER
3-TRITYLSULFANYL-PROPIONIC ACID
2-氯-5-(三氟甲基)吡啶-3-磺酰胺
4-乙基硝基苯
4,7-二氮杂螺[2.5]辛烷-4-甲酸叔丁酯
DIETHYL (3-(METHOXYCARBONYL)PHENYL)METHYLPHOSPHONATE
oxygen(-2) anion
METHYL BROMOACETATE SOLUTION 100UG/ML IN T-BUTYLMETHYL ETHER 5X1ML
5-氟-2-甲基-3-硝基苯甲酸甲酯 2-甲基-3-硝基-5-氟苯甲酸甲酯
LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-GLY-ALA-PRO-LEU-ALA-PRO-ARG-ASP-ALA-GLY SER